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KEY NF-B SYSTEM COMPONENTS IN TUMORS OF BREAST CANCER PATIENTS
Contemporary knowledge about the molecular mechanisms of breast cancer development and progression and its sensitivity or resistance to various drugs allows to proceed from standardized averaged therapy regimens to so called “personalized medicine”, i.e. to the prescription of treatment according to the individual patient’s features and biological characteristics of the tumor. This paper contains original data and a review of up to date publications on the role of nuclear transcription factor NF-B and related signaling proteins in the generation of breast cancer hormone and drug resistance, and the prospects of their clinical application.
nuclear transcription factor NF-kappa B; NF-Bp65; NF-Bp50; IB; protein kinase Akt1; steroid hormone receptors; HER2/neu; breast cancer; hormone sensitivity; resistance.
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