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Conventional osteosarcoma


Osteosarcoma (OS) - a malignant bone tumor that arises from bone-forming mesenchyme and characterized by production of osteoid and atypical bone structures proliferating malignant tumor cells. OS cells arise from multipotential mesenchymal nature, capable of differentiating into cartilage or bone direction. Although the OS detects signs often chondrosarcoma and fibrosarcoma, all these tumors, and in the first place, the operating system must be strictly differentiate between them. OS etiology is unknown in most cases. The most common site of the operating system are long bones. The majority (about 80 %) of the operating system develops in the metaphysis of long bones of the knee area (distal metaphysis of the femur, proximal metaphysis tibial and fibula) and the proximal metaphysis of the humerus. These parts of the skeleton are physiologically most responsible for the growth of the skeleton; it is here that occur most active growth processes of bone formation; and, apparently, they also represent a high probability of malignant transformation. For the diagnosis of OS is critical comparison of radiographic lesion with morphological changes, or rather, the mandatory analysis of X-ray pictures before analysis of histological or cytological preparations. On the basis of aggregate data identify several clinicopathological variants of the OS. There are now also being investigated OC at the genetic level in order to develop more effective treatments for this tumor, since 5-year survival rate for metastatic dissemination is extremely low (20-25 %).


osteosarcoma; osteoid; primary bone sarcoma

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