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Role of nuclear proliferating antigen and p53 in the tumor process in gastric cancer


Was made the review of literature about the meaning of nuclear proliferating antigen(PCNA) and protein p53 in tumor progression at gastric cancer. Was showed that PCNA depends on the level of invasion of tumor in the side of stomach, stage of process, the size of tumor and may serve as a marker for evaluating aggression of tumor process. Were given data that the level of expression of protein p53 is connected with the form, degree of invasion, and also the localization of tumor in stomach. The authors showed that mutation of p53 in tumor grows at localization of tumor in cardinal segment. Was also studied the frequency of mutations of p53 in tumor textile at 26 people having gastric cancer. Wherein was revealed tendency to its growing as was growing the level of invasion. Were showed the meanings of PNCA and p53 for the length of life of people having gastric cancer.


early gastric cancer; proliferating nuclear antigen; p53; tumor progression; prediction

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