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Investigation of the asymmetry parameter of the optic nerve in multiple sclerosis with the OCT

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Background: in Russia among patients with multiple sclerosis (MS) disability reaches 78 %. There are about 3 million people with MS and more than 200 thousand people with this decease are in Russia. The method of optical coherence tomography (OCT) is informative in the diagnosis of optic atrophy in MS, but there are no data in the available literature illustrating neurodegenerative changes in each segment of the optic nerve and the differences between the best in functional parameters and the worst eye using OCT method. Purpose: to evaluate segmental asymmetry of optic disk’s parameters with OCT in optic nerve atrophy due to MS. Materials and methods: the study involved 40 people (80 eyes) out of which 25 % were men, 75 % – women. Mean age was 36 ± 1.5 years. All patients underwent complete neuro-ophthalmological examination including standard research methods and OCT (Cirrus HD-ОСТ (“Carl Zeiss Meditec Inc.”)) by protocols: Ganglion Cell Analysis, Macula Thickness OU, ONM and RNFL OU Analysis). Results: received significant (p < 0.05) decrease in the nerve fiber layer thickness compared with normative data. It is noted that with the optic nerve atrophy in MS decreases not only nerve fiber layer thickness in the temporal segment of the optic disk, but in the nose segment too. The nerve fiber layer thickness on the worst average eye has been reduced by 23 % compared with the best eye that confirms asymmetry of the beginning and development of atrophy process in multiple sclerosis. The nerve fiber layer thicknesses in the temporal segment of the optic disk were correlated (r = 0.7; p < 0.05) with the ganglion cell layer thicknesses. Conclusion: we have obtained reliable data on the asymmetry of the process of atrophy of the optic nerve in two eyes which should be considered when supervision of patient with MS.

Keywords

multiple sclerosis; optical coherence tomography; optic nerve atrophy; retinal nerve fiber layer; neurodegeneration

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DOI

10.20310/1810-0198-2016-21-4-1559-1563

UDC

617.7

Pages

1559-1563

References

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Received

2016-03-23

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